Pain is the main reason people nowadays seek medical help. It can interfere with work, sleep, activities of daily living and the general quality of life. Pain relievers are one of the most common prescriptions and sought after drugs in the market. Hydrocodone and Acetaminophen are examples of these medications. Hydrocodone belongs to a group of drugs called narcotic pain relievers while Acetaminophen is a less potent pain reliever that increases the effects of hydrocodone. A combination of both is used to relieve moderate to severe pain.

Pill imprint Watson 853 is also known as Acetaminophen and hydrocodone bitartrate 325 mg / 10 mg and belongs to the drug class narcotic pain relievers. It is used to treat back pain, cough, rheumatoid arthritis, pain, and many more.


Oral capsule, oral elixir, oral liquid, oral solution, oral syrup, oral tablet


a) General

• Do not use this medication if you are allergic to acetaminophen (Tylenol) or hydrocodone.
• Should be taken with increased fiber diet and 6 to 8 full glasses of water daily to help prevent constipation.
• Be careful when driving or doing activities that require you to be awake and alert. Acetaminophen and hydrocodone can cause side effects that may impair your thinking or reactions.
• Avoid drinking alcohol while taking this medicine as it increases the risk for liver damage.
• Inform the doctor if you plan to get pregnant, or if you are pregnant or breastfeeding. It may be harmful to the unborn and nursing baby.
• Caution with use to elderly. They are sensitive to effects of this medicine.
• Do not immediately stop taking the medication or take in larger amounts, or use it for longer than recommended by your doctor.
• Take exactly as prescribed and follow directions on the prescription label. Measure the liquid form with a dose-measuring device, overdose can harm the liver.

b) Clinical

• Inform your treating physician that you are taking acetaminophen and hydrocodone as it may alter urine tests.
• Inform the doctor of any past and present illnesses or diseases as well as any medications taken.
• Inform the doctor that you are taking the medicine before undergoing surgery.

c) Storage

• Store acetaminophen and hydrocodone at room temperature away from moisture and heat.
• Keep in a secure place. Hydrocodone is a habit-forming drug and must not be used by anyone to whom it is not prescribed.

Side Effects

a) Minor Side Effects

• feeling anxious, dizzy, or drowsy;
• mild nausea, vomiting, upset stomach, constipation;
• headache, mood changes;
• blurred vision;
• ringing in your ears; or
• dry mouth

**Stop taking the medicine and call the doctor with these symptoms:

b) Allergic Reactions

• hives; difficulty breathing; swelling of your face, lips, tongue, or throat

c) Major Side Effects

• shallow breathing, slow heartbeat;
• feeling light-headed, fainting;
• confusion, fear, unusual thoughts or behavior;
• seizure (convulsions);
• problems with urination; or
• nausea, stomach pain, loss of appetite, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Signs of Overdose

• extreme drowsiness, sweating, pinpoint pupils, nausea, vomiting, dark urine, jaundice (yellowing of the skin or eyes), confusion, cold and clammy skin, muscle weakness, fainting, weak pulse, slow heart rate, coma, blue lips, shallow breathing, or no breathing.

Seek emergency help in case of an overdose as this can be fatal and talk to your doctor about any side effect that seems unusual or bothersome.

This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.

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